|
KMID : 0545120080180121984
|
|
Journal of Microbiology and Biotechnology
2008 Volume.18 No. 12 p.1984 ~ p.1989
|
|
|
Surfactin Blocks NO Production in Lipopolysaccharide-activated Macrophages by Inhibiting NF-κB Activation
|
|
Byeon Se-Eun
Lee Yong-Gyu
Kim Byung-Hun
Shen Ting
Lee Sang-Yeol
Park Hwa-Jin
Park Seung-Chun
Rhee Man-Hee
Cho Jae-Youl
|
|
|
Abstract
|
|
|
|
Surfactin is a natural biosurfactant derived from Bacillus subtilis and has various biological activities such as anticancer, antiplatelet, and anti-inflammatory effects. In this study, the inhibitory mechanism of surfactin in NO production from macrophages was examined. Surfactin downregulated LPSinduced NO production in RAW264.7 cells and primary macrophages with IC50 values of 31.6 and 22.4 μM, respectively. Immunoblotting analysis showed that surfactin strongly blocked the phosphorylation of IKK and IkBa and the nuclear translocation of NF-κB (p65). Therefore, these data suggest that surfactin may act as a bacterium-derived antiinflammatory agent with anti-NF-κB activity.
|
|
|
KEYWORD
|
|
|
Surfactin, Bacillus subtilis, nitric oxide, antiinflammatory effect, lipopolysaccharide, NF-κB
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|